Loperamide abuse and cardiotoxicity
نویسندگان
چکیده
منابع مشابه
Loperamide abuse and cardiotoxicity
With increasing restrictions and safety protocols implemented in prescribing opioids, there has been an increased incidence of recreational abuse of over-thecounter medications, including loperamide. Loperamide is a peripherally-acting μ-opioid receptor agonist in the gastrointestinal tract which, if taken at high doses, can cross the blood-brain barrier to produce euphoria and analgesia effects.
متن کاملHigh-dose loperamide abuse–associated ventricular arrhythmias
Charles W. O’Connell, MD, Amir A. Schricker, MD, MS, Aaron B. Schneir, MD, Imir G. Metushi, PhD, Ulrika Birgersdotter-Green, MD, Alicia B. Minns, MD From the Division of Medical Toxicology, Department of Emergency Medicine, University of California San Diego, San Diego, California, Department of Emergency Medicine, Veterans Association San Diego, La Jolla, California, Division of Cardiovascular...
متن کاملVentricular Tachycardia Triggered by Loperamide and Famotidine Abuse
A 32-year-old male developed recurrent ventricular tachycardia after taking mega doses of loperamide and famotidine in order to experience an opiate-like euphoric effect. He was taking up to 200 mg of loperamide and multiple doses of famotidine each day. He developed palpitations and syncope. Electrocardiography demonstrated ventricular tachycardia and QT interval prolongation (corrected QT int...
متن کاملLoperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015.
STUDY OBJECTIVE With the increasing amount of information available on the Internet describing techniques for using loperamide either for self-treatment of opioid withdrawal syndromes or for recreational use (so-called legal highs), the objective was to describe a statewide poison control system's experience with loperamide misuse and abuse, with specific interest in cases of cardiotoxicity, an...
متن کاملVentricular fibrillation due to overdose of loperamide, the “poor man’s methadone”
Loperamide is an over-the-counter antidiarrheal agent that is considered by many patients to be safe, but has been used as a drug of abuse due to its opioid properties. However, cardiotoxicity has been reported, prompting the FDA to release a warning regarding the arrhythmogenic potential of loperamide. We present a case of a 38-year-old female presenting with cardiac arrest thought to be secon...
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ژورنال
عنوان ژورنال: Journal of Community Hospital Internal Medicine Perspectives
سال: 2017
ISSN: 2000-9666
DOI: 10.1080/20009666.2017.1361294